Ndufs4 Gene Summary [Rat]
Predicted to contribute to NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in response to cAMP. Predicted to act upstream of or within several processes, including adult walking behavior; mitochondrial respiratory chain complex I assembly; and nervous system development. Predicted to be located in mitochondrion. Predicted to be part of respiratory chain complex I. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in Leigh disease and nuclear type mitochondrial complex I deficiency 1. Orthologous to human NDUFS4 (NADH:ubiquinone oxidoreductase subunit S4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndufs4 |
| Official Name | NADH:ubiquinone oxidoreductase subunit S4 [Source:RGD Symbol;Acc:1594380] |
| Ensembl ID | ENSRNOG00000011383 |
| Bio databases IDs | |
| Aliases | NADH:ubiquinone oxidoreductase subunit S4 |
| Synonyms | 18 kda subunit of complex i, 6720411N02RIK, AQDQ, C1-18k, CI-18, CI-18 kDa, CI-AQDQ, Complex I-18 kDa, MC1DN1, NADH:ubiquinone oxidoreductase core subunit S4, NADH:ubiquinone oxidoreductase subunit S4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ndufs4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme
- protein binding
- NADH2 dehydrogenase (ubiquinone)
- NADH dehydrogenase ubiquinone Fe-S protein 4
Pathways
Biological processes and signaling networks where the Ndufs4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dyspnea
- hypotonia
- nuclear type 1 mitochondrial complex I deficiency
- obesity
- Leigh syndrome
- COVID-19
- seizures
- multiple sclerosis
- chromophobe renal cell carcinoma
- chromophobe renal cancer
role in cell
- apoptosis
- formation
- abnormal morphology
- degeneration
- morphology
- loss
- development
- cycling
- sprouting angiogenesis by
- cycling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ndufs4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- reactive oxygen species metabolic process
- transmembrane transport
- regulation of protein phosphorylation
- mitochondrial electron transport, NADH to ubiquinone
- positive regulation of fibroblast proliferation
- response to cAMP
- cellular respiration
- mitochondrial respiratory chain complex I assembly
- brain development
- aerobic respiration
- mitochondrial ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- respiratory chain complex I
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- NADH dehydrogenase (ubiquinone) activity