Tdgf1

Predicted to enable several functions, including Wnt-protein binding activity; coreceptor activity; and signaling receptor binding activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; circulatory system development; and regionalization. Predicted to act upstream of or within several processes, including circulatory system development; negative regulation of transforming growth factor beta receptor signaling pathway; and positive regulation of macromolecule metabolic process. Predicted to be located in several cellular components, including apical plasma membrane; membrane raft; and perinuclear region of cytoplasm. Predicted to be active in cell surface and extracellular region. Human ortholog(s) of this gene implicated in colon cancer and congenital heart disease. Orthologous to several human genes including CRIPTO (cripto, EGF-CFC family member). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tdgf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Tdgf1 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Tdgf1 gene, providing context for its role in the cell.