Gdf3 Gene Summary [Rat]
Predicted to enable cytokine activity and protein kinase binding activity. Predicted to be involved in several processes, including negative regulation of BMP signaling pathway; negative regulation of epidermal cell differentiation; and positive regulation of fat cell differentiation. Predicted to act upstream of or within several processes, including anterior/posterior axis specification; negative regulation of myoblast differentiation; and response to dietary excess. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Klippel-Feil syndrome 3 and isolated microphthalmia 7. Orthologous to human GDF3 (growth differentiation factor 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gdf3 |
| Official Name | growth differentiation factor 3 [Source:RGD Symbol;Acc:1564178] |
| Ensembl ID | ENSRNOG00000015331 |
| Bio databases IDs | |
| Aliases | growth differentiation factor 3 |
| Synonyms | ecat9, growth differentiation factor 3, KFS3, MCOP7, MCOPCB6, RGD1564178, Vgr-2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gdf3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- TGF_beta_SF
- Transforming growth factor beta like domain
- protein binding
- growth factor
- TGF-beta propeptide
Pathways
Biological processes and signaling networks where the Gdf3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- isolated microphthalmia type 7
- isolated microphthalmia with coloboma type 6
- chordoma
- bone cancer
- autosomal dominant Klippel-Feil syndrome type 3
role in cell
- proliferation
- apoptosis
- growth
- differentiation
- abnormal morphology
- thermogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gdf3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of epidermal cell differentiation
- signal transduction
- endoderm development
- mesoderm development
- positive regulation of fat cell differentiation
- response to dietary excess
- formation of anatomical boundary
- negative regulation of BMP signaling pathway
- eye development
- skeletal system development
- notochord development
- in utero embryonic development
- negative regulation of myoblast differentiation
- regulation of cell fate commitment
- somite rostral/caudal axis specification
- primitive streak formation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- growth factor activity
- cytokine activity