Idh3a Gene Summary [Rat]
Enables isocitrate dehydrogenase (NAD+) activity. Predicted to be involved in isocitrate metabolic process and tricarboxylic acid cycle. Predicted to be part of isocitrate dehydrogenase complex (NAD+). Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in retinitis pigmentosa 90. Orthologous to human IDH3A (isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Idh3a |
| Official Name | isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha [Source:RGD Symbol;Acc:70889] |
| Ensembl ID | ENSRNOG00000010277 |
| Bio databases IDs | |
| Aliases | isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha |
| Synonyms | 1110003P10Rik, 1500012E04Rik, isocitrate dehydrogenase 3 (NAD+) alpha, isocitrate dehydrogenase 3 (NAD+) α, isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha, isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit α, Isocitrate/isopropylmalate Dehydrogenase, RP90 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Idh3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Isocitrate/isopropylmalate dehydrogenase
- tartrate dehydrogenase
- isocitrate dehydrogenase (NAD)
- enzyme
- protein binding
- magnesium ion binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- retinitis pigmentosa type 90
- Huntington disease
- psoriasis
- breast cancer
- Alzheimer disease
- retinitis pigmentosa
- retinal dystrophy
- osteoporosis
regulates
- HIF1A
- alpha-hydroxyglutarate
- 2-oxoglutaric acid
role in cell
- accumulation in
- glycolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- Mitochondria
- cytosol
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Idh3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- isocitrate metabolic process
- tricarboxylic acid cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- isocitrate dehydrogenase (NAD+) activity
- protein binding
- NAD binding