Nsdhl Gene Summary [Rat]
Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in cholesterol metabolic process. Predicted to act upstream of or within hair follicle development; labyrinthine layer blood vessel development; and smoothened signaling pathway. Predicted to be located in lipid droplet. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in CHILD syndrome and CK syndrome. Orthologous to human NSDHL (NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nsdhl |
| Official Name | NAD(P) dependent steroid dehydrogenase-like [Source:RGD Symbol;Acc:1359337] |
| Ensembl ID | ENSRNOG00000057814 |
| Bio databases IDs | |
| Aliases | NAD(P) dependent steroid dehydrogenase-like |
| Synonyms | Av017044, Bpa, H105E3, NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL, NAD(P) dependent 3-β-hydroxysteroid dehydrogenase NSDHL, NAD(P) dependent steroid dehydrogenase-like, Nadp-dependent steroid dehydrogenase-like, SDR31E1, Str, XAP104 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nsdhl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- Male sterility protein
- 3-beta hydroxysteroid dehydrogenase/isomerase family
- 3beta-hydroxy-delta5-steroid dehydrogenase
- NAD dependent epimerase/dehydratase family
- enzyme
- protein binding
- C-3 sterol dehydrogenase (C-4 sterol decarboxylase)
- 3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)
- GDP-mannose 4,6 dehydratase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- CHILD syndrome
- CK syndrome
- experimental autoimmune encephalomyelitis
- obesity
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
regulates
- cholesterol
role in cell
- growth
- biosynthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- endoplasmic reticulum mitochondria contact site
- Nucleus
- Endoplasmic Reticulum
- lipid droplets
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nsdhl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- hair follicle development
- labyrinthine layer blood vessel development
- cholesterol metabolic process
- cholesterol biosynthetic process
- smoothened signaling pathway
Cellular Component
Where in the cell the gene product is active
- lipid particle
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- 3-beta-hydroxy-delta5-steroid dehydrogenase activity
- C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
- protein binding
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
- sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity