Lims1 Gene Summary [Rat]
Predicted to enable protein kinase binding activity and zinc ion binding activity. Predicted to be involved in several processes, including positive regulation of cell-substrate adhesion; positive regulation of signal transduction; and regulation of gene expression. Predicted to act upstream of or within several processes, including cell-matrix adhesion; negative regulation of cell population proliferation; and negative regulation of hepatocyte apoptotic process. Part of protein-containing complex. Orthologous to human LIMS1 (LIM zinc finger domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lims1 |
| Official Name | LIM zinc finger domain containing 1 [Source:RGD Symbol;Acc:1560732] |
| Ensembl ID | ENSRNOG00000037765 |
| Bio databases IDs | |
| Aliases | LIM zinc finger domain containing 1 |
| Synonyms | 2310016J22Rik, 4921524A02Rik, C430041B13RIK, LIM and senescent cell antigen-like domains 1, Lims1l, LIM zinc finger domain containing 1, PINCH, PINCH-1, RGD1560732 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lims1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protein kinase binding
- zinc ion binding
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- protein binding
Pathways
Biological processes and signaling networks where the Lims1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- cancer
- neoplasia
- liver cancer
- epithelial cancer
- epithelial neoplasia
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- lung adenocarcinoma
role in cell
- expression in
- proliferation
- synthesis in
- quantity
- apoptosis
- phosphorylation in
- formation
- formation in
- differentiation
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- perinuclear region
- focal adhesions
- Nucleus
- intercellular junctions
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lims1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of substrate adhesion-dependent cell spreading
- cell-cell junction organization
- positive regulation of GTPase activity
- establishment of protein localization
- cellular response to transforming growth factor beta stimulus
- tumor necrosis factor-mediated signaling pathway
- positive regulation of focal adhesion assembly
- negative regulation of transcription, DNA-dependent
- positive regulation of gene expression
- epithelial to mesenchymal transition
- positive regulation of cell-substrate adhesion
- regulation of epithelial cell proliferation
- positive regulation of integrin-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- perinuclear region of cytoplasm
- focal adhesion
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- zinc ion binding
- protein binding