Rsu1 Gene Summary [Rat]
Predicted to be involved in intracellular signal transduction; positive regulation of GTPase activity; and positive regulation of cell-substrate adhesion. Predicted to act upstream of or within Ras protein signal transduction and positive regulation of neural precursor cell proliferation. Predicted to be located in focal adhesion. Orthologous to human RSU1 (Ras suppressor protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rsu1 |
| Official Name | Ras suppressor protein 1 [Source:RGD Symbol;Acc:1591781] |
| Ensembl ID | ENSRNOG00000017595 |
| Bio databases IDs | |
| Aliases | Ras suppressor protein 1 |
| Synonyms | LOC102548876, LOC684929, Ras suppressor protein 1, RSP-1, RsuI |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rsu1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- leucine-rich repeat
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat
- protein binding
- Leucine Rich repeats (2 copies)
Pathways
Biological processes and signaling networks where the Rsu1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioblastoma
- juvenile dermatomyositis
- migraines
- pervasive developmental disorder
- glioblastoma cancer
- major depression
- silicosis
- metabolic syndrome X
- coronary artery disease
- autosomal dominant Emery-Dreifuss muscular dystrophy
role in cell
- migration
- activation in
- proliferation
- contact growth inhibition
- extension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- focal adhesions
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rsu1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- positive regulation of cell-substrate adhesion
- regulation of cell-substrate adhesion
- positive regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- focal adhesion
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding