Hormad2 Gene Summary [Rat]
Predicted to be involved in meiotic cell cycle and meiotic sister chromatid cohesion. Predicted to be located in centrosome; cytosol; and nuclear lumen. Orthologous to human HORMAD2 (HORMA domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hormad2 |
| Official Name | HORMA domain containing 2 [Source:RGD Symbol;Acc:1565447] |
| Ensembl ID | ENSRNOG00000037865 |
| Bio databases IDs | |
| Aliases | HORMA domain containing 2 |
| Synonyms | 4930529M09Rik, CT46.2, HORMA domain containing 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hormad2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- HORMA domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Crohn disease
- ulcerative colitis
- IgA nephropathy
- kidney disease
- cataract
- pain
- non-insulin-dependent diabetes mellitus
- insulin-dependent diabetes mellitus
- hypothyroidism
- thyroid disease
regulated by
- TGF beta
- EWSR1-FLI1
- RNF2
- MEIOSIN/STRA8
regulates
role in cell
- formation
- apoptosis
- number
- meiosis
- lack
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- centrosome
- cytosol
- chromosome
- nucleoplasm
- synaptonemal complexes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hormad2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- meiotic cell cycle
- meiotic sister chromatid cohesion
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytosol
- chromosome
- synaptonemal complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding