Sirt2 Gene Summary [Rat]
Enables NAD-dependent protein lysine deacetylase activity and tubulin deacetylase activity. Involved in several processes, including regulation of nervous system development; regulation of postsynaptic neurotransmitter receptor internalization; and tubulin deacetylation. Located in several cellular components, including Schmidt-Lanterman incisure; lateral loop; and main axon. Is active in glutamatergic synapse. Used to study high grade glioma and metabolic dysfunction-associated steatotic liver disease. Biomarker of cocaine dependence and intermittent claudication. Orthologous to human SIRT2 (sirtuin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sirt2 |
| Official Name | sirtuin 2 [Source:RGD Symbol;Acc:621481] |
| Ensembl ID | ENSRNOG00000020102 |
| Bio databases IDs | |
| Aliases | sirtuin 2 |
| Synonyms | 5730427M03Rik, SIR2, SIR2L, SIR2L2, sirtuin 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sirt2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- NAD ADP-ribosyltransferase
- NAD-dependent histone deacetylase activity (H4-K16 specific)
- transcription factor binding
- histone deacetylase binding
- chromatin binding
- ubiquitin binding
- protein binding
- enzyme
- protein deacetylase activity
- NAD or NADH binding
- NAD-dependent histone deacetylase
- binding protein
- zinc ion binding
- histone deacetylase
- tubulin deacetylase
- SIR2
- Non-amino-acyl group acyltransferase
- histone acetyltransferase binding
Pathways
Biological processes and signaling networks where the Sirt2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- epithelial neoplasia
- epithelial cancer
- cancer
- cardiac hypertrophy
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- neoplasia
role in cell
- expression in
- proliferation
- survival
- migration
- differentiation
- apoptosis
- growth
- maturation
- accumulation in
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- myelin enriched fraction
- glutaminergic synapse
- axon component
- heterochromatin
- spindle apparatus
- Cytoplasm
- perinuclear region
- Plasma Membrane
- centrosome
- centriole
- Mitochondria
- microtubules
- midbody
- cytosol
- chromosome
- nucleoli
- spindle fibers
- myelin sheath outer loop
- paranodal loops
- paranodes
- paranodal junctions
- myelin sheath
- Schmidt-Lanterman incisures
- glial cell projections
- mitotic spindle
- meiotic spindles
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sirt2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of oocyte maturation
- cellular response to caloric restriction
- regulation of exit from mitosis
- negative regulation of protein catabolic process
- positive regulation of DNA binding
- positive regulation of transcription from RNA polymerase II promoter
- post-translational protein modification
- positive regulation of execution phase of apoptosis
- negative regulation of striated muscle tissue development
- positive regulation of fatty acid biosynthetic process
- cell division
- negative regulation of transcription from RNA polymerase II promoter
- myelination in peripheral nervous system
- meiotic cell cycle
- negative regulation of transcription, DNA-dependent
- positive regulation of cell division
- chromatin silencing at rDNA
- cellular response to epinephrine stimulus
- autophagy
- cellular lipid catabolic process
- negative regulation of oligodendrocyte progenitor proliferation
- peptidyl-lysine deacetylation
- regulation of cell cycle
- cellular response to hypoxia
- positive regulation of attachment of spindle microtubules to kinetochore
- negative regulation of reactive oxygen species metabolic process
- mitotic nuclear envelope reassembly
- positive regulation of meiosis
- negative regulation of fat cell differentiation
- protein deacetylation
- tubulin deacetylation
- NLRP3 inflammasome complex assembly
- negative regulation of NLRP3 inflammasome complex assembly
- regulation of phosphorylation
- substantia nigra development
- regulation of gene expression, epigenetic
- response to redox state
- proteasomal ubiquitin-dependent protein catabolic process
- telomeric heterochromatin assembly
- negative regulation of peptidyl-threonine phosphorylation
- negative regulation of autophagy
- innate immune response
- heterochromatin assembly
- regulation of myelination
- cellular response to oxidative stress
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- myelin sheath
- chromosome
- nucleolus
- perikaryon
- chromatin silencing complex
- microtubule
- growth cone
- chromosome, telomeric region
- mitotic spindle
- cytosol
- meiotic spindle
- lateral loop
- paranode region of axon
- paranodal junction
- juxtaparanode region of axon
- plasma membrane
- nucleus
- heterochromatin
- centrosome
- perinuclear region of cytoplasm
- cytoplasm
- centriole
- Schmidt-Lanterman incisure
- mitochondrion
- spindle
- midbody
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- histone acetyltransferase binding
- tubulin deacetylase activity
- histone deacetylase binding
- chromatin binding
- transcription factor binding
- NAD+ ADP-ribosyltransferase activity
- protein binding
- NAD-dependent protein deacetylase activity
- ubiquitin binding
- NAD-dependent histone deacetylase activity (H4-K16 specific)
- histone deacetylase activity
- NAD-dependent histone deacetylase activity
- protein deacetylase activity
- NAD+ binding