Rps19l2 Gene Summary [Rat]
Enables translation initiation factor binding activity. A structural constituent of ribosome. Predicted to be involved in several processes, including monocyte chemotaxis; regulation of respiratory burst involved in inflammatory response; and ribosomal small subunit biogenesis. Predicted to act upstream of or within Notch signaling pathway. Located in nucleolus. Part of cytosolic small ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia and Diamond-Blackfan anemia 1. Orthologous to human RPS19 (ribosomal protein S19). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rps19l2 |
| Official Name | ribosomal protein S19-like2 [Source:RGD Symbol;Acc:68440] |
| Ensembl ID | ENSRNOG00000037897 |
| Bio databases IDs | |
| Aliases | ribosomal protein S19-like2 |
| Synonyms | DBA, DBA1, Dsk3, eS19, LOH19CR1, Ribosomal Protein S19, Rps19l2, S19 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rps19l2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of ribosome
- protein kinase binding
- fibroblast growth factor binding
- Ribosomal protein S19e
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Rps19l2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- myelodysplastic syndrome
- neoplasia
- Diamond-Blackfan anemia
- macrocytic anemia
- diamond blackfan anemia type 1
- epithelial cancer
- Alzheimer disease
- pancreatic carcinoma
- pancreatic epithelial cancer
- systemic autoimmune syndrome
role in cell
- differentiation
- apoptosis
- phosphorylation in
- expression in
- cell death
- processing in
- colony formation
- proliferation
- formation
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pre-ribosome
- cellular membrane
- ribosome
- cytosol
- nucleoplasm
- nucleoli
- synapse
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rps19l2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of respiratory burst involved in inflammatory response
- negative regulation of respiratory burst involved in inflammatory response
- defense response to Gram-negative bacterium
- nucleolus organization
- maturation of SSU-rRNA
- cytoplasmic translation
- ribosomal small subunit assembly
- rRNA processing
- translation
- maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- erythrocyte differentiation
- monocyte chemotaxis
- ribosomal small subunit biogenesis
- killing of cells of other organism
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- small-subunit processome
- cytosolic ribosome
- cytosolic small ribosomal subunit
- ribosome
- nucleolus
- nucleoplasm
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- protein binding
- RNA binding
- structural constituent of ribosome
- fibroblast growth factor binding