Upf3b Gene Summary [Rat]
Predicted to enable mRNA binding activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay and positive regulation of translation. Predicted to act upstream of or within positive regulation of mRNA cis splicing, via spliceosome. Predicted to be located in several cellular components, including centriolar satellite; neuronal cell body; and nucleoplasm. Predicted to be part of exon-exon junction complex. Predicted to be active in cytoplasm and nucleolus. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability 14. Orthologous to human UPF3B (UPF3B regulator of nonsense mediated mRNA decay). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Upf3b |
| Official Name | UPF3B, regulator of nonsense mediated mRNA decay [Source:RGD Symbol;Acc:1560264] |
| Ensembl ID | ENSRNOG00000039994 |
| Bio databases IDs | |
| Aliases | UPF3B, regulator of nonsense mediated mRNA decay |
| Synonyms | 5730594O13Rik, AI317193, AW541158, HUPF3B, MRX62, MRX82, MRXS14, RENT3B, RGD1560264, UPF3BP1, UPF3BP2, UPF3BP3, UPF3B regulator of nonsense mediated mRNA decay, UPF3B, regulator of nonsense mediated mRNA decay, UPF3 regulator of nonsense transcripts homolog B (yeast), UPF3X |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Upf3b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- mRNA binding
- protein binding
- Smg-4/UPF3 family
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- X linked mental retardation syndromic 14
- hereditary disorder
- COVID-19
- diabetic nephropathy
- familial amyotrophic lateral sclerosis
- neurodevelopmental disorder
- X-linked complex neurodevelopmental disorder
- cervical cancer
- mental retardation
- productive infection by HIV-1
role in cell
- differentiation
- expression in
- morphogenesis
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- cytosol
- nucleoplasm
- nucleoli
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Upf3b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translation
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- neuron projection development
- positive regulation of neuron differentiation
- brain development
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- exon-exon junction complex
- cytoplasm
- centriolar satellite
- cytosol
- neuronal cell body
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA binding