Upf3b Gene Summary [Mouse]
Predicted to enable mRNA binding activity. Acts upstream of or within nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; positive regulation of mRNA cis splicing, via spliceosome; and random inactivation of X chromosome. Located in neuronal cell body and nucleus. Is expressed in several structures, including central nervous system. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability 14. Orthologous to human UPF3B (UPF3B regulator of nonsense mediated mRNA decay). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Upf3b |
| Official Name | UPF3 regulator of nonsense transcripts homolog B (yeast) [Source:MGI Symbol;Acc:MGI:1915384] |
| Ensembl ID | ENSMUSG00000036572 |
| Bio databases IDs | |
| Aliases | UPF3 regulator of nonsense transcripts homolog B (yeast) |
| Synonyms | 5730594O13Rik, AI317193, AW541158, HUPF3B, MRX62, MRX82, MRXS14, RENT3B, RGD1560264, UPF3BP1, UPF3BP2, UPF3BP3, UPF3B regulator of nonsense mediated mRNA decay, UPF3B, regulator of nonsense mediated mRNA decay, UPF3 regulator of nonsense transcripts homolog B (yeast), UPF3X |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Upf3b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- mRNA binding
- protein binding
- Smg-4/UPF3 family
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- X linked mental retardation syndromic 14
- hereditary disorder
- COVID-19
- diabetic nephropathy
- familial amyotrophic lateral sclerosis
- neurodevelopmental disorder
- X-linked complex neurodevelopmental disorder
- cervical cancer
- mental retardation
- productive infection by HIV-1
role in cell
- differentiation
- expression in
- morphogenesis
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- cytosol
- nucleoplasm
- nucleoli
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Upf3b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translation
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- neuron projection development
- positive regulation of neuron differentiation
- brain development
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- exon-exon junction complex
- cytoplasm
- centriolar satellite
- cytosol
- neuronal cell body
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA binding