Upf1 Gene Summary [Rat]
Predicted to enable several functions, including ATP hydrolysis activity; helicase activity; and telomeric DNA binding activity. Predicted to be involved in DNA metabolic process; cell cycle phase transition; and regulation of macromolecule metabolic process. Predicted to act upstream of or within positive regulation of mRNA cis splicing, via spliceosome. Predicted to be located in chromosome; cytosol; and nucleoplasm. Predicted to be part of exon-exon junction complex and supraspliceosomal complex. Predicted to be active in cytoplasm. Orthologous to human UPF1 (UPF1 RNA helicase and ATPase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Upf1 |
| Official Name | UPF1, RNA helicase and ATPase [Source:RGD Symbol;Acc:1589127] |
| Ensembl ID | ENSRNOG00000020134 |
| Bio databases IDs | |
| Aliases | UPF1, RNA helicase and ATPase |
| Synonyms | B430202H16RIK, HUPF1, NORF1, NORP1 (regulator of nonsense), PNORF-1, RENT1, smg-2, UPF1 RNA helicase and ATPase, UPF1, RNA helicase and ATPase, Upflp, UTF |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Upf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ZBD_UPF1_nv_SF1_Hel-like
- DNA helicase, putative
- chromatin binding
- enzyme
- protein binding
- ATPase
- RNA helicase
- telomeric DNA binding
- DNA helicase
- AAA domain
- RNA binding
- helicase domain
- binding protein
- RNA helicase UPF1, 1B domain
- 1B_UPF1_nv_SF1_Hel-like
- N-terminal helicase domain of the DEAD-box helicase superfamily
- RNA helicase (UPF2 interacting domain)
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- latent tuberculosis
- schizophrenia
- familial colorectal cancer
- adenosquamous pancreatic carcinoma
- adenosquamous pancreatic cancer
- mental retardation
- familial amyotrophic lateral sclerosis
role in cell
- response
- survival
- expression in
- number
- proliferation
- binding in
- quantity
- apoptosis
- invasion by
- cell survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- polyribosome fractions
- GW body
- Cytoplasm
- cytosol
- spliceosomes
- nucleoplasm
- telomeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Upf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- positive regulation of mRNA catabolic process
- 3'-UTR-mediated mRNA destabilization
- DNA replication
- nuclear-transcribed mRNA catabolic process
- mRNA export from nucleus
- regulation of translational termination
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- cellular response to lipopolysaccharide
- histone mRNA catabolic process
- DNA duplex unwinding
- cellular response to interleukin-1
- telomere maintenance via semi-conservative replication
- regulation of telomere maintenance
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- exon-exon junction complex
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- supraspliceosomal complex
- cytoplasmic mRNA processing body
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- zinc ion binding
- RNA binding
- protein binding
- RNA helicase activity
- telomeric DNA binding
- double-stranded DNA-dependent ATP-dependent DNA helicase activity
- helicase activity
- chromatin binding