Cd209a Gene Summary [Rat]
Predicted to enable D-mannose binding activity; carbohydrate derivative binding activity; and pattern recognition receptor activity. Predicted to be involved in immune response. Predicted to be located in cell surface. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in Coronavirus infectious disease; aspergillosis; dengue disease (multiple); human immunodeficiency virus infectious disease (multiple); and tuberculosis (multiple). Orthologous to human CD209 (CD209 molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd209a |
| Official Name | CD209a antigen [Source:RGD Symbol;Acc:1308239] |
| Ensembl ID | ENSRNOG00000040128 |
| Bio databases IDs | |
| Aliases | CD209a antigen |
| Synonyms | Cd209a, CD209a molecule, CD209 molecule, CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1, GP120 binding, hDC-SIGN, MDC-SIGN1, SDC-SIGN1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cd209a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- virion binding
- extracellular domain
- viral receptor
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- carbohydrate recognition domain
- tyrosine internalization motif
- protein binding
- mannose binding
- internalization targeting signal
- dileucine internalization motif
- binding protein
- cytoplasmic domain
- transmembrane domain
- Lectin C-type domain
- cytosolic tail domain
- neck domain
Pathways
Biological processes and signaling networks where the Cd209a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- susceptibility to human immunodeficiency virus type 1
- androgenic alopecia
- susceptibility to tuberculosis
- human immunodeficiency virus I infection
- diabetic nephropathy
- epithelial thyroid cancer
- tuberculosis
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
role in cell
- formation
- proliferation
- production in
- expression in
- activation in
- activation
- migration
- function
- binding
- clustering
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- raft fractions
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- plasma membrane extracellular face
- microdomains
- early endosomes
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cd209a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of T cell proliferation
- viral entry into host cell
- interspecies interaction between organisms
- heterophilic cell-cell adhesion
- adaptive immune response
- positive regulation of T cell proliferation
- endocytosis
- cell-cell recognition
- peptide antigen transport
- leukocyte cell-cell adhesion
- viral attachment to host cell
- immune response
- innate immune response
- viral genome replication
- antigen processing and presentation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- external side of plasma membrane
- extracellular region
- plasma membrane
- host cell
- cell surface
Molecular Function
What the gene product does at the molecular level
- virion binding
- peptide antigen binding
- mannose binding
- protein binding
- metal ion binding
- viral receptor activity
- carbohydrate binding