Mmp27 Gene Summary [Rat]
Predicted to enable metalloendopeptidase activity. Predicted to be involved in collagen catabolic process and extracellular matrix organization. Predicted to be located in endoplasmic reticulum. Orthologous to human MMP27 (matrix metallopeptidase 27). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mmp27 |
| Official Name | matrix metallopeptidase 27 [Source:RGD Symbol;Acc:1306642] |
| Ensembl ID | ENSRNOG00000040208 |
| Bio databases IDs | |
| Aliases | matrix metallopeptidase 27 |
| Synonyms | Gm180, matrix metallopeptidase 27 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mmp27 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Putative peptidoglycan binding domain
- Hemopexin-like repeats
- Matrixin
- ZnMc
- peptidase
- HX
- Zinc-dependent metalloprotease
Pathways
Biological processes and signaling networks where the Mmp27 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Axonal Guidance Signaling
- Bladder Cancer Signaling
- Colorectal Cancer Metastasis Signaling
- Estrogen Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- HIF1α Signaling
- Inhibition of Matrix Metalloproteases
- Leukocyte Extravasation Signaling
- Molecular Mechanisms of Cancer
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- breast cancer
- osteoarthritis
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- pseudoxanthoma elasticum
- Dupuytren contracture
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mmp27 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- extracellular matrix organization
- collagen catabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular space
- extracellular matrix
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- metalloendopeptidase activity