Rfx1 Gene Summary [Rat]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Orthologous to human RFX1 (regulatory factor X1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rfx1 |
| Official Name | regulatory factor X1 [Source:RGD Symbol;Acc:1306574] |
| Ensembl ID | ENSRNOG00000006049 |
| Bio databases IDs | |
| Aliases | regulatory factor X1 |
| Synonyms | EFC, regulatory factor X1, regulatory factor X, 1 (influences HLA class II expression), RFX |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rfx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RFX DNA-binding domain
- transcription regulator
- double-stranded DNA binding
- RFX1 transcription activation region
- protein binding
- sequence-specific DNA binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast adenocarcinoma
- Barrett syndrome
- esophageal adenocarcinoma
- esophageal carcinoma formation
role in cell
- expression in
- production in
- phosphorylation in
- proliferation
- DNA methylation in
- degradation in
- transcription in
- M2 polarization
- M1 polarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rfx1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity