Stard3 Gene Summary [Rat]
Predicted to enable cholesterol binding activity and protein homodimerization activity. Predicted to be involved in cholesterol transport and vesicle tethering to endoplasmic reticulum. Predicted to act upstream of or within progesterone biosynthetic process. Predicted to be located in several cellular components, including endosome; nucleoplasm; and organelle membrane contact site. Predicted to be active in endoplasmic reticulum-endosome membrane contact site and late endosome membrane. Predicted to colocalize with endoplasmic reticulum membrane. Orthologous to human STARD3 (StAR related lipid transfer domain containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stard3 |
| Official Name | StAR-related lipid transfer domain containing 3 [Source:RGD Symbol;Acc:1549768] |
| Ensembl ID | ENSRNOG00000042044 |
| Bio databases IDs | |
| Aliases | StAR-related lipid transfer domain containing 3 |
| Synonyms | CAB1, es64, MLN64, StAR-related lipid transfer domain containing 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Stard3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SRPBCC domain
- cholesterol binding
- Cholesterol-capturing domain
- protein homodimerization
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiovascular disorder
- asthma
- neoplasia
- organismal death
- breast cancer
- mammary neoplasm
role in cell
- accumulation in
- degradation in
- expression in
- phosphorylation in
- migration
- proliferation
- morphology
- colony formation
- cell cycle progression
- dispersion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- mitochondrial fraction
- intracellular membrane-bounded organelle
- intracellular space
- perinuclear region
- cellular membrane
- endosomes
- vesicles
- Mitochondria
- cytosol
- vesicle membrane
- endoplasmic reticulum membrane
- endosomal membrane
- nucleoplasm
- late endosomes
- organelle membrane contact site
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Stard3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- progesterone biosynthetic process
- mitochondrial transport
- lipid metabolic process
- cholesterol metabolic process
- steroid metabolic process
- cholesterol transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- late endosome membrane
- endosome
- cytoplasm
- organelle membrane contact site
- intracellular membrane-bounded organelle
- mitochondrion
- cytosol
- lysosomal membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- cholesterol binding