Rgs10 Gene Summary [Rat]
Predicted to enable G-protein alpha-subunit binding activity and GTPase activator activity. Involved in response to amphetamine. Located in axon terminus; dendritic spine; and neuronal cell body. Biomarker of opioid abuse. Orthologous to human RGS10 (regulator of G protein signaling 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rgs10 |
| Official Name | regulator of G-protein signaling 10 [Source:RGD Symbol;Acc:3562] |
| Ensembl ID | ENSRNOG00000042592 |
| Bio databases IDs | |
| Aliases | regulator of G-protein signaling 10 |
| Synonyms | 2310010N19Rik, regulator of G-protein signaling 10, Regulator of G-protein signalling 10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rgs10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulator of G protein signaling domain
- conserved domain
- Regulator of G protein signaling (RGS) domain superfamily
- GTPase
- GTPase activator
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Rgs10 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- heart failure
- dilated cardiomyopathy
- cardiac hypertrophy
- perivascular fibrosis
- interstitial fibrosis
- microgliosis
- osteopetrosis
- androgenic alopecia
- left ventricular dysfunction
role in cell
- phosphorylation in
- production in
- cell death
- activation in
- expression in
- survival
- differentiation
- quantity
- number
- production
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
- nuclear bodies
- nuclear rim
- dendritic spines
- perikaryon
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rgs10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of signal transduction
- G-protein coupled receptor signaling pathway
- G-protein coupled acetylcholine receptor signaling pathway
- regulation of G-protein coupled receptor protein signaling pathway
- positive regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytosol
- synapse
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- G-protein alpha-subunit binding
- GTPase activity
- GTPase activator activity