Fgf13 Gene Summary [Rat]
Predicted to enable sodium channel regulator activity; transmembrane transporter binding activity; and tubulin binding activity. Involved in response to odorant. Predicted to be located in several cellular components, including growth cone; intercalated disc; and lateral plasma membrane. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 90 and non-syndromic X-linked intellectual disability. Orthologous to human FGF13 (fibroblast growth factor 13). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fgf13 |
| Official Name | fibroblast growth factor 13 [Source:RGD Symbol;Acc:620164] |
| Ensembl ID | ENSRNOG00000042753 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor 13 |
| Synonyms | DEE90, Fgf1c, FGF2, FHF-2, fibroblast growth factor 13, LINC00889, LOC730528, XLID110 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fgf13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- protein kinase activator
- microtubule binding
- beta-trefoil_FGF
- ion channel binding
- sodium channel regulator
- protein binding
- growth factor
Pathways
Biological processes and signaling networks where the Fgf13 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- seizures
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- epilepsy
- developmental and epileptic encephalopathy type 90
- Alzheimer disease
- Huntington disease
- Parkinson disease
- congenital generalized hypertrichosis
role in cell
- expression in
- proliferation
- phosphorylation in
- apoptosis
- formation
- synthesis in
- quantity
- migration
- branching
- depolymerization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- Nucleus
- Plasma Membrane
- microtubules
- intercellular junctions
- cytosol
- lateral plasma membrane
- nucleoli
- growth cone
- neurites
- filopodia
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fgf13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- cell-cell signaling
- nervous system development
- negative regulation of microtubule depolymerization
- microtubule polymerization
- branching morphogenesis of a nerve
- hippocampus development
- learning
- memory
- cerebral cortex cell migration
- MAPK cascade
- negative regulation of collateral sprouting
- sodium ion transport
- neuron migration
- establishment of neuroblast polarity
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- lateral plasma membrane
- neuron projection
- plasma membrane
- microtubule
- growth cone
- dendrite
- nucleus
- cytoplasm
- sarcolemma
- cytosol
- filopodium
- intercalated disc
- axon
Molecular Function
What the gene product does at the molecular level
- sodium channel regulator activity
- growth factor activity
- protein binding
- beta-tubulin binding
- ion channel binding
- microtubule binding