Hdhd2 Gene Summary [Rat]
Predicted to enable enzyme binding activity and phosphatase activity. Predicted to be involved in several processes, including organ growth; positive regulation of secretion by cell; and regulation of fibroblast apoptotic process. Predicted to act upstream of or within several processes, including glucose homeostasis; insulin metabolic process; and type B pancreatic cell differentiation. Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hdhd2 |
| Official Name | haloacid dehalogenase-like hydrolase domain containing 2 [Source:RGD Symbol;Acc:1308579] |
| Ensembl ID | ENSRNOG00000043171 |
| Bio databases IDs | |
| Aliases | haloacid dehalogenase-like hydrolase domain containing 2 |
| Synonyms | 0610039H12Rik, 3110052N05Rik, haloacid dehalogenase-like hydrolase domain containing 2, HEL-S-301, Ier3ip1, LRRG00122, RGD1308579 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hdhd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Haloacid Dehalogenase Superfamily Class (subfamily) IIA
- HAD-hyrolase-like
- phosphoglycolate/pyridoxal phosphate phosphatase family
- enzyme binding
- HAD-superfamily subfamily IIA hydrolase, TIGR01458
- protein binding
- Haloacid Dehalogenase-like Hydrolases
- HAD hydrolase, family IA, variant 3
- HAD-superfamily class IIA hydrolase, TIGR01456, CECR5
- haloacid dehalogenase-like hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hdhd2 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- phosphatase activity
- enzyme binding