Arc Gene Summary [Rat]
Enables mRNA binding activity. Involved in several processes, including learning or memory; positive regulation of AMPA receptor activity; and regulation of synaptic plasticity. Located in actin cytoskeleton and extracellular vesicle. Is active in glutamatergic synapse; postsynaptic density membrane; and postsynaptic endosome. Used to study anxiety disorder and morphine dependence. Biomarker of anxiety disorder; middle cerebral artery infarction; and withdrawal disorder. Orthologous to human ARC (activity regulated cytoskeleton associated protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arc |
| Official Name | activity-regulated cytoskeleton-associated protein [Source:RGD Symbol;Acc:62037] |
| Ensembl ID | ENSRNOG00000043465 |
| Bio databases IDs | |
| Aliases | activity-regulated cytoskeleton-associated protein |
| Synonyms | activity regulated cytoskeletal-associated protein, activity-regulated cytoskeleton-associated protein, Arc3.1, Arg3.1, hArc, mArc, rg3.1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Arc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA binding
- Arc MA domain
- actin binding
- protein binding
- structural molecule
- Arc C-lobe
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- diabetic nephropathy
- Alzheimer disease
- growth failure
- epileptic seizure
- tinnitus
- brain edema
- gastrulation failure
role in cell
- apoptosis
- activation in
- formation
- number
- organization
- signaling in
- plasticity
- generation in
- long-term potentiation
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- thorny excrescence
- extracellular vesicles
- cytoplasmic ribonucleoprotein granule
- cytoskeleton
- actin cytoskeleton
- Plasma Membrane
- endosomes
- cytosol
- synaptic membrane
- dendritic spines
- membrane rafts
- postsynaptic spines
- perikaryon
- dendrites
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Arc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of dendritic spine morphogenesis
- regulation of long-term synaptic potentiation
- regulation of cell morphogenesis
- cytoskeleton organization
- regulation of long term synaptic depression
- endoderm development
- anterior/posterior pattern specification
- protein homooligomerization
- response to morphine
- endocytosis
- learning
- dendritic spine morphogenesis
- long-term memory
- response to ethanol
- regulation of neuronal synaptic plasticity
- regulation of synaptic transmission
- long-term synaptic potentiation
- cell migration
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- neuronal cell body
- plasma membrane
- early endosome membrane
- cytoplasm
- acrosomal vesicle
- cell cortex
- membrane raft
- dendritic spine
- actin cytoskeleton
- cytosol
- neuronal ribonucleoprotein granule
- clathrin coated vesicle membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural molecule activity
- mRNA binding