Chst12 Gene Summary [Rat]
Predicted to enable chondroitin 4-sulfotransferase activity. Predicted to be involved in proteoglycan biosynthetic process. Predicted to be located in Golgi membrane. Biomarker of hypertension. Orthologous to human CHST12 (carbohydrate sulfotransferase 12). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chst12 |
| Official Name | carbohydrate sulfotransferase 12 [Source:RGD Symbol;Acc:1308214] |
| Ensembl ID | ENSRNOG00000001252 |
| Bio databases IDs | |
| Aliases | carbohydrate sulfotransferase 12 |
| Synonyms | C4S-2, C4ST-2, carbohydrate sulfotransferase 12, carbohydrate sulphotransferase 12, Chondroitin 4-o-sulfotransferase, Chondroitin 4-o-sulphotransferase, FLJ00049, LOC100288594, LOC100291271, LOC100293682, LOC101927181 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Chst12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme
- chondroitin 4-sulfotransferase
- Sulfotransferase family
Pathways
Biological processes and signaling networks where the Chst12 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Chst12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chondroitin sulfate biosynthetic process
- dermatan sulfate biosynthetic process
- carbohydrate biosynthetic process
- proteoglycan biosynthetic process
Cellular Component
Where in the cell the gene product is active
- membrane
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- chondroitin 4-sulfotransferase activity
- sulfotransferase activity
- 3'-phosphoadenosine 5'-phosphosulfate binding