Sema6b Gene Summary [Rat]
Predicted to enable chemorepellent activity and semaphorin receptor binding activity. Predicted to be involved in several processes, including nervous system development; neural crest cell migration; and semaphorin-plexin signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy. Orthologous to human SEMA6B (semaphorin 6B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sema6b |
| Official Name | semaphorin 6B [Source:RGD Symbol;Acc:69278] |
| Ensembl ID | ENSRNOG00000045998 |
| Bio databases IDs | |
| Aliases | semaphorin 6B |
| Synonyms | EPM11, Sema, sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B, SEMAN, Semaphorin 6B, Semaphorin N, SEMA-VIB, semaZ, SEM-SEMA-Y, SEM-SEMA-Z, VIb |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sema6b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- semaphorin domain
- semaphorin receptor binding
- protein binding
- Sema domain
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the Sema6b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- diabetic nephropathy
- progressive myoclonic epilepsy type 11
- mental retardation
- myoclonic-astatic epilepsy
- proliferative diabetic retinopathy
role in cell
- proliferation
- guidance
- rearrangement in
- rearrangement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sema6b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative chemotaxis
- central nervous system development
- neural crest cell migration
- axon guidance
- hippocampus development
- semaphorin-plexin signaling pathway
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- chemorepellent activity
- semaphorin receptor binding