Exoc4 Gene Summary [Rat]
Enables PDZ domain binding activity and ionotropic glutamate receptor binding activity. Involved in several processes, including Golgi to transport vesicle transport; oligodendrocyte differentiation; and regulation of protein localization. Located in several cellular components, including dendritic shaft; growth cone; and postsynaptic density. Part of protein-containing complex. Is active in Schaffer collateral - CA1 synapse; postsynaptic density, intracellular component; and synaptic vesicle. Orthologous to human EXOC4 (exocyst complex component 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Exoc4 |
| Official Name | exocyst complex component 4 [Source:RGD Symbol;Acc:621791] |
| Ensembl ID | ENSRNOG00000046023 |
| Bio databases IDs | |
| Aliases | exocyst complex component 4 |
| Synonyms | ALR, exocyst complex component 4, LOC105375513, RSEC8, SEC8, SEC8L1, Sec8p |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Exoc4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protein binding
- ionotropic glutamate receptor binding
- transporter
- PDZ-domain binding
Pathways
Biological processes and signaling networks where the Exoc4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- cervical cancer
- Waldenström macroglobulinemia
- breast adenocarcinoma
- non-small cell lung cancer
- schizophrenia
- cervical carcinoma
- nephrosis
- epithelial uterine cancer
- Alzheimer disease
regulates
- D-glucose
- Ca2+
- tubulin
role in cell
- differentiation
- formation
- formation in
- biogenesis
- formation by
- outgrowth
- outgrowth in
- targeting
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- soluble fraction
- low-density microsomal fraction
- organelle
- perinuclear region
- Plasma Membrane
- endosomes
- centrosome
- lysosome
- midbody
- cytosol
- myelin sheath outer loop
- synaptic vesicles
- growth cone
- neurites
- myelin sheath inner loop
- synapse
- Schmidt-Lanterman incisures
- perinuclear vesicles
- actin stress fibers
- tight junctions
- microvilli
- cell membrane leading edge
- perikaryon
- axons
- dendrites
- postsynaptic density
- dendritic shafts
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Exoc4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transmembrane transport
- paraxial mesoderm formation
- membrane fission
- cytokinesis after mitosis
- vesicle docking involved in exocytosis
- Golgi to plasma membrane transport
- regulation of macroautophagy
- synaptic transmission
- exocytosis
Cellular Component
Where in the cell the gene product is active
- centrosome
- microvillus
- cytoplasm
- membrane
- cytosol
- growth cone membrane
- synapse
- myelin sheath abaxonal region
- plasma membrane
- exocyst
Molecular Function
What the gene product does at the molecular level
- protein binding
- PDZ domain binding