Exoc3 Gene Summary [Rat]

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
Exoc3
Official Name
exocyst complex component 3 [Source:RGD Symbol;Acc:621790]
Ensembl ID
ENSRNOG00000039776
Bio databases IDs NCBI: 252881 Ensembl: ENSRNOG00000039776
Aliases exocyst complex component 3
Synonyms 2810050O03RIK, E430013E20Rik, exocyst complex component 3, rSec6, SEC6, SEC6L1, Sec6p
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Exoc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Exocyst complex component Sec6
  • protein binding
  • transporter

Pathways

Biological processes and signaling networks where the Exoc3 gene in rat plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • hypospadia
regulated by
  • insulin
  • latrunculin B
  • TARDBP
  • NCAM1
  • brefeldin A
  • FGFR
  • puromycin aminonucleoside
  • CST5
  • gentamicin
  • guanosine triphosphate
regulates

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • microsomal fraction
  • microtubule fractions
  • low-density microsomal fraction
  • Cytoplasm
  • cell periphery
  • perinuclear region
  • cellular membrane
  • actin filaments
  • cell-cell contacts
  • secretory granule membrane
  • cytosol
  • apical membrane
  • presynaptic membrane
  • growth cone
  • perinuclear vesicles
  • cortical actin filaments
  • tight junctions
  • filopodia
  • cell membrane leading edge
  • perikaryon
  • axons
  • dendrites
  • axon branches
  • cytosolic fraction

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Exoc3 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • membrane fission
  • cytokinesis after mitosis
  • protein transport
  • vesicle docking involved in exocytosis
  • exocytosis
  • exocyst localization

Cellular Component

Where in the cell the gene product is active
  • growth cone
  • presynaptic membrane
  • secretory granule membrane
  • perinuclear region of cytoplasm
  • cytosol
  • Golgi apparatus
  • midbody
  • exocyst

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • cadherin binding
  • SNARE binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.