Pnmt Gene Summary [Rat]
Enables phenylethanolamine N-methyltransferase activity. Involved in several processes, including adrenal gland development; catecholamine metabolic process; and cellular response to dexamethasone stimulus. Located in axon; dendrite; and perikaryon. Biomarker of hypertension and hypoglycemia. Human ortholog(s) of this gene implicated in Alzheimer's disease; hypertension; and multiple sclerosis. Orthologous to human PNMT (phenylethanolamine N-methyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pnmt |
| Official Name | phenylethanolamine-N-methyltransferase [Source:RGD Symbol;Acc:3361] |
| Ensembl ID | ENSRNOG00000046057 |
| Bio databases IDs | |
| Aliases | phenylethanolamine-N-methyltransferase |
| Synonyms | PENT, phenylethanolamine-N-methyltransferase, PNMTase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pnmt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- methyltransferase
- transferase
- phenylethanolamine N-methyltransferase
- enzyme
- protein binding
- AdoMet_MTases
- S-adenosylmethionine-dependent methyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- cardiovascular disorder
- pancreatic epithelial cancer
- weight loss
- heart failure
- adrenal medullary hyperplasia
- idiopathic pulmonary fibrosis
- pancreatic carcinoma
regulates
- norepinephrine
- epinephrine
- S-adenosylmethionine
- S-adenosylhomocysteine
- CHKA
- catecholamine
- PLA2
- CCT (family)
role in cell
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- axon component
- cytosol
- cytoplasmic vesicles
- perikaryon
- axons
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pnmt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epinephrine biosynthetic process
- catecholamine biosynthetic process
- methylation
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- phenylethanolamine N-methyltransferase activity
- protein binding