Cyp11a1 Gene Summary [Rat]
Predicted to enable cholesterol monooxygenase (side-chain-cleaving) activity and heme binding activity. Involved in several processes, including cellular response to cytokine stimulus; nervous system development; and steroid biosynthetic process. Located in mitochondrial crista and perikaryon. Biomarker of several diseases, including glucose metabolism disease (multiple); hypertension; nephrosis; sciatic neuropathy; and status epilepticus. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia and congenital adrenal insufficiency. Orthologous to human CYP11A1 (cytochrome P450 family 11 subfamily A member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyp11a1 |
| Official Name | cytochrome P450, family 11, subfamily a, polypeptide 1 [Source:RGD Symbol;Acc:69325] |
| Ensembl ID | ENSRNOG00000008074 |
| Bio databases IDs | |
| Aliases | cytochrome P450, family 11, subfamily a, polypeptide 1 |
| Synonyms | CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME, Cscc, CYP11A, CYPXIA1, cytochrome P450 family 11 subfamily A member 1, cytochrome P450, family 11, subfamily a, polypeptide 1, D9Ertd411e, Erato Doi 411, P450SCC, P450(scc), Scc |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cyp11a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- cholesterol binding
- cholesterol monooxygenase (side-chain-cleaving)
- enzyme
- protein binding
- heme binding
- NADH2 or NADPH2 1 atom incorporation:oxygen oxidoreductase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Alzheimer disease
- ulcerative colitis
- congenital adrenal insufficiency with partial or complete 46,XY sex reversal
- Cushing syndrome
- chronic obstructive pulmonary disease
- preeclampsia
- endogenous Cushings syndrome
- Crohn disease
- feminization
role in cell
- expression in
- binding in
- phosphorylation in
- apoptosis
- proliferation
- G2/M phase
- activation in
- migration
- abnormal morphology
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular compartment
- intracellular space
- outer membranes
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cyp11a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glucocorticoid biosynthetic process
- cortisol metabolic process
- cellular response to peptide hormone stimulus
- cholesterol metabolic process
- C21-steroid hormone biosynthetic process
- sterol metabolic process
- vitamin D metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cholesterol monooxygenase (side-chain-cleaving) activity
- iron ion binding
- heme binding