Chka Gene Summary [Rat]
Enables ATP binding activity; choline binding activity; and phosphotransferase activity, alcohol group as acceptor. Involved in several processes, including choline metabolic process; ethanolamine metabolic process; and response to 3-methylcholanthrene. Predicted to be located in lipid droplet. Predicted to be active in cytosol. Biomarker of colon cancer and transient cerebral ischemia. Orthologous to human CHKA (choline kinase alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chka |
| Official Name | choline kinase alpha [Source:RGD Symbol;Acc:61944] |
| Ensembl ID | ENSRNOG00000016791 |
| Bio databases IDs | |
| Aliases | choline kinase alpha |
| Synonyms | Chetk-alpha, Chetk-α, CHK, ChoK, CHOLINE KINASE, choline kinase alpha, choline kinase α, CK, CKalpha, CK/EK-alpha, CK/EK-α, CKI, CK-R, EK, EtnK-alpha, EtnK-α, NEDMIMS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Chka often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- cholinesterase
- binding protein
- Protein Kinases, catalytic domain
- ATP binding
- Phosphotransferase enzyme family
- protein homodimerization
- ethanolamine kinase
- protein binding
- protein-tyrosine kinase
- identical protein binding
- choline kinase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodevelopmental disorder with microcephaly, movement abnormalities, and seizures
- head and neck neoplasia
- streptozotocin induced type1 diabetes
- pituitary gland adenoma
- adenoma formation
- head and neck neuroendocrine neoplasia
role in cell
- expression in
- proliferation
- apoptosis
- activation in
- phosphorylation in
- growth
- binding in
- disassembly
- survival
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- lipid droplets
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Chka gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid transport
- phosphatidylethanolamine biosynthetic process
- CDP-choline pathway
- lipid metabolic process
- phosphatidylcholine biosynthetic process
Cellular Component
Where in the cell the gene product is active
- lipid particle
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein homodimerization activity
- ethanolamine kinase activity
- cholinesterase activity
- choline kinase activity