LOC689574 Gene Summary [Rat]
Predicted to be involved in positive regulation of NLRP3 inflammasome complex assembly and positive regulation of interleukin-1 beta production. Predicted to be located in mitochondrial intermembrane space and mitochondrial outer membrane. Predicted to be active in mitochondrial respirasome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | LOC689574 |
| Official Name | hypothetical protein LOC689574 [Source:RGD Symbol;Acc:1591053] |
| Ensembl ID | ENSRNOG00000046109 |
| Bio databases IDs | |
| Aliases | hypothetical protein LOC689574 |
| Synonyms | 1810058I24Rik, C7orf73, LOC641845, LOC683960, Mitolamban, Mm47, Mtbln, Mtlbn, PL-5283, short transmembrane mitochondrial protein 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Loc689574 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF4535)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- reperfusion injury
- cardiomyopathy
regulated by
- lipopolysaccharide
- poly rI:rC-RNA
- Pam3-Cys-Ser-Lys4
- TNF
- CpG ODN 2006
- CL097
- IFN alpha/beta
role in cell
- expression in
- production in
- quantity
- activation
- morphology
- fusion
- transmembrane potential
- disorganization
- assembly in
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial intermembrane space
- mitochondrial outer membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Loc689574 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial respiratory chain complex IV assembly
- mitochondrial respiratory chain complex III assembly
- innate immune response
- mitochondrial respiratory chain supercomplex assembly
- positive regulation of NLRP3 inflammasome complex assembly
- positive regulation of interleukin-1 beta production
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- mitochondrial respiratory chain
- mitochondrial outer membrane
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding