Ctdspl Gene Summary [Rat]
Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of G1/S transition of mitotic cell cycle and negative regulation of protein phosphorylation. Orthologous to human CTDSPL (CTD small phosphatase like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ctdspl |
| Official Name | CTD small phosphatase like [Source:RGD Symbol;Acc:1304841] |
| Ensembl ID | ENSRNOG00000046257 |
| Bio databases IDs | |
| Aliases | CTD small phosphatase like |
| Synonyms | 2810418J22RIK, C3orf8, CTD small phosphatase like, CTDSP-like, HYA22, NIFL, NIF-like, PSR1, RBSP3, SCP3, YA22 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ctdspl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FCP1-like phosphatase, phosphatase domain
- protein binding
- Haloacid Dehalogenase-like Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- schizophrenia
- neoplasia
- epithelial cancer
- side effect
- breast carcinoma
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- breast cancer
- renal cell carcinoma
role in cell
- expression in
- growth
- survival
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ctdspl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein phosphorylation
- negative regulation of G1/S transition of mitotic cell cycle
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- CTD phosphatase activity
- myosin phosphatase activity