Smad1 Gene Summary [Rat]
Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; SMAD binding activity; and enzyme binding activity. Involved in several processes, including BMP signaling pathway; cardiac muscle hypertrophy in response to stress; and positive regulation of dendrite morphogenesis. Predicted to be located in cytoplasm and nuclear inner membrane. Predicted to be part of heteromeric SMAD protein complex and homomeric SMAD protein complex. Predicted to be active in chromatin and male germ cell nucleus. Used to study pulmonary hypertension. Biomarker of glomerulonephritis; male infertility; nephrotic syndrome; and pulmonary hypertension. Orthologous to human SMAD1 (SMAD family member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smad1 |
| Official Name | SMAD family member 1 [Source:RGD Symbol;Acc:3030] |
| Ensembl ID | ENSRNOG00000018483 |
| Bio databases IDs | |
| Aliases | SMAD family member 1 |
| Synonyms | BSP-1, DKFZP586M0622, dwf-A, JV4-1, Mad1, MADH1, MADR1, Mlp1, mMad1, MusMLP, SMAD family member 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Smad1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- ubiquitin protein ligase binding
- SMAD binding
- transcription regulator
- MH2 domain
- protein kinase binding
- nuclear export signal
- MH domain
- nucleic acid binding
- inhibitory domain
- linker domain
- protein binding
- sequence-specific DNA binding
- identical protein binding
- N-terminal Mad Homology 1 (MH1) domain
- effector domain
- RNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- DEAD/H-box RNA helicase binding
- MH1 domain
- C-terminal Mad Homology 2 (MH2) domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Smad1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- BMP signaling pathway
- Cardiomyocyte Differentiation via BMP Receptors
- Cellular Effects of Sildenafil (Viagra)
- Factors Promoting Cardiogenesis in Vertebrates
- HIPPO signaling
- Human Embryonic Stem Cell Pluripotency
- Iron homeostasis signaling pathway
- Molecular Mechanisms of Cancer
- Mouse Embryonic Stem Cell Pluripotency
- Osteoarthritis Pathway
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- TGF-β Signaling
- Transcriptional Regulatory Network in Embryonic Stem Cells
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- pulmonary hypertensive arterial disease
- neoplasia
- colorectal cancer
- organismal death
- tumorigenesis
- vertebral segmentation anomaly
- sagittal cleft vertebra
- chorioallantoic membrane fusion failure
- epilepsy
role in cell
- expression in
- invasion by
- migration
- proliferation
- apoptosis
- upregulation in
- growth
- induction in
- binding in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- inner nuclear membrane
- nucleoplasm
- nuclear envelope
- chromatin
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Smad1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cartilage development
- negative regulation of cell proliferation
- transforming growth factor beta receptor signaling pathway
- transcription from RNA polymerase II promoter
- gamete generation
- anatomical structure morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of osteoblast differentiation
- bone development
- negative regulation of muscle cell differentiation
- MAPK cascade
- midbrain development
- inflammatory response
- ossification
- hindbrain development
- BMP signaling pathway
- primary miRNA processing
- signal transduction
- transcription, DNA-dependent
- embryonic pattern specification
- cardiac conduction system development
- SMAD protein signal transduction
- osteoblast fate commitment
- cardiac muscle cell proliferation
- regulation of transcription from RNA polymerase II promoter
- mesodermal cell fate commitment
- ureteric bud development
- homeostatic process
- positive regulation of gene expression
- cell differentiation
- cellular response to organic cyclic compound
- cartilage development
Cellular Component
Where in the cell the gene product is active
- SMAD protein complex
- nucleus
- SMAD2 protein complex
- nuclear inner membrane
- cytoplasm
- SMAD2-SMAD3 protein complex
- membrane
- cytosol
- macromolecular complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- sequence-specific DNA binding transcription factor activity
- ubiquitin protein ligase binding
- protein binding
- metal ion binding
- DEAD/H-box RNA helicase binding
- co-SMAD binding
- I-SMAD binding
- primary miRNA binding