Wipf1 Gene Summary [Rat]
Predicted to enable SH3 domain binding activity; cytoskeletal anchor activity; and protein folding chaperone. Involved in actin cytoskeleton organization and positive regulation of protein export from nucleus. Located in actin filament. Orthologous to human WIPF1 (WAS/WASL interacting protein family member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wipf1 |
| Official Name | WAS/WASL interacting protein family, member 1 [Source:RGD Symbol;Acc:620887] |
| Ensembl ID | ENSRNOG00000018406 |
| Bio databases IDs | |
| Aliases | WAS/WASL interacting protein family, member 1 |
| Synonyms | D2Ertd120e, IMAGE:5264268, LOC108350583, PRPL-2, WAS2, WASPIP, WAS/WASL interacting protein family member 1, WAS/WASL interacting protein family, member 1, WIP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Wipf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wiskott Aldrich syndrome homology region 2
- protein binding
- polyproline motif
- WASP-binding domain
- Nck-binding domain
- WH2 motif
- SH3-domain binding
- cytoskeletal adaptor
- profilin binding
- verprolin homology domain
- actin-binding domain
- WH2
- actin binding
Pathways
Biological processes and signaling networks where the Wipf1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atrial fibrillation
- Wiskott-Aldrich syndrome type 2
- glomerulonephritis
- androgenic alopecia
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- osteonecrosis
- colitis
- lymphomagenesis
- peripheral T-cell lymphoma
role in cell
- expression in
- differentiation
- proliferation
- activation in
- function
- survival
- endocytosis by
- formation
- polymerization
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- lysosome fractions
- invadopodia
- perinuclear region
- podosomes
- actin cytoskeleton
- cell cortex
- actin filaments
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Wipf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- actin polymerization or depolymerization
- response to other organism
- actin filament-based movement
- protein folding
Cellular Component
Where in the cell the gene product is active
- actin cytoskeleton
- ruffle
- cytosol
- cytoplasmic vesicle
- actin filament
Molecular Function
What the gene product does at the molecular level
- protein binding involved in protein folding
- protein binding
- actin binding
- SH3 domain binding
- profilin binding