Zmat3 Gene Summary [Rat]
This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Zmat3 |
| Official Name | zinc finger, matrin type 3 [Source:RGD Symbol;Acc:620134] |
| Ensembl ID | ENSRNOG00000010119 |
| Bio databases IDs | |
| Aliases | zinc finger, matrin type 3 |
| Synonyms | BC036485, PAG608, WIG-1, zinc finger matrin-type 3, zinc finger, matrin type 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Zmat3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc-finger double-stranded RNA-binding
- nuclear localization sequence
- U1 zinc finger
- protein binding
- zinc finger domain
- Zinc-finger of C2H2 type
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- post-traumatic stress disorder
- pain
- depressive disorder
- papillary thyroid carcinoma
- papillary thyroid cancer
- refractive error
role in cell
- apoptosis
- expression in
- cell death
- growth
- transmembrane potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Zmat3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic process
- protein transport
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- nucleolus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- RNA binding