Thpo Gene Summary [Rat]
Predicted to enable cytokine activity and hormone activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; megakaryocyte development; and positive regulation of intracellular signal transduction. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in aplastic anemia; congenital amegakaryocytic thrombocytopenia 2; essential thrombocythemia; thrombocytopenia; and thrombocytosis. Orthologous to human THPO (thrombopoietin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Thpo |
| Official Name | thrombopoietin [Source:RGD Symbol;Acc:621438] |
| Ensembl ID | ENSRNOG00000046850 |
| Bio databases IDs | |
| Aliases | thrombopoietin |
| Synonyms | CAMT2, LOC100910397, MGDF, MKCSF, ML, MPLLG, THC9, THCYT1, THCYTX, Thpol1, Thrombopoietin, thrombopoietin like 1, TPO |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Thpo often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- secretory leader domain
- Erythropoietin-like domain
- Erythropoietin/thrombopoietin
- glycan domain
- cytokine
- growth factor
Pathways
Biological processes and signaling networks where the Thpo gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cirrhosis
- Sjögren syndrome
- neoplasia
- hemorrhagic disease
- thrombocytosis
- congenital amegakaryocytic thrombocytopenia II
- thrombocytopenia type 9
- hereditary disorder
- thrombocythemia 1
- asthma
role in cell
- cell death
- activation in
- apoptosis
- survival
- generation
- proliferation
- quantity
- expression in
- activation
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane processes
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Thpo gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- megakaryocyte differentiation
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of protein phosphorylation
- positive regulation of cell proliferation
- megakaryocyte development
- positive regulation of megakaryocyte differentiation
- thrombopoietin-mediated signaling pathway
- positive regulation of MAPK cascade
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- cytokine activity
- receptor binding
- hormone activity