Dbi Gene Summary [Rat]
Enables benzodiazepine receptor binding activity and fatty-acyl-CoA binding activity. Involved in several processes, including conditioned place preference; positive regulation of release of sequestered calcium ion into cytosol; and regulation of lipid metabolic process. Acts upstream of or within regulation of GABAergic synaptic transmission. Located in contractile muscle fiber; extracellular space; and synaptic vesicle. Biomarker of morphine dependence. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human DBI (diazepam binding inhibitor, acyl-CoA binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dbi |
| Official Name | diazepam binding inhibitor, acyl-CoA binding protein [Source:RGD Symbol;Acc:2490] |
| Ensembl ID | ENSRNOG00000046889 |
| Bio databases IDs | |
| Aliases | diazepam binding inhibitor, acyl-CoA binding protein |
| Synonyms | ACABP, ACBD1, ACBP, Acoabp3, ACYL-COA binding, CCK-RP, diazepam binding inhibitor, diazepam binding inhibitor, acyl-CoA binding protein, endozepine, EP, Homolog to endozepine-related protein precursor, Lcrf, LOC100365425, LOC679040, Odn, RNACOABP3, Ttn |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dbi often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acyl-CoA binding
- protein binding
- identical protein binding
- benzodiazepine receptor binding
- ACBP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- amyotrophic lateral sclerosis
- alopecia
- Alzheimer disease
- growth failure
- oxygen-induced retinopathy
- heroin dependence
- proliferative diabetic retinopathy
- colon epithelial cancer
- anxiety disorders with panic attacks
- colon carcinoma
role in cell
- proliferation
- expression in
- production in
- number
- mitogenesis
- formation in
- hypertrophy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- perinuclear region
- cellular membrane
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- apical cytoplasm
- reticular perinuclear compartment
- endoplasmic reticulum lumen
- Golgi membrane
- mitochondrial outer membrane
- nucleoplasm
- synaptic vesicles
- myofibrils
- rough endoplasmatic reticulum
- peroxisomes
- membrane processes
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dbi gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of phospholipid transport
- phosphatidylcholine acyl-chain remodeling
- fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular vesicular exosome
- protein-lipid complex
- endoplasmic reticulum
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- fatty-acyl-CoA binding
- long-chain fatty acyl-CoA binding
- benzodiazepine receptor binding