Il6r Gene Summary [Rat]
Predicted to enable several functions, including cytokine binding activity; cytokine receptor activity; and protein homodimerization activity. Predicted to contribute to ciliary neurotrophic factor receptor activity and interleukin-6 receptor binding activity. Involved in several processes, including response to cAMP; response to gamma radiation; and response to lipopolysaccharide. Located in extracellular space and neuronal cell body membrane. Biomarker of congestive heart failure; depressive disorder; myocardial infarction; orchitis; and sciatic neuropathy. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; hyper IgE syndrome; obesity; and stomach cancer. Orthologous to human IL6R (interleukin 6 receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il6r |
| Official Name | interleukin 6 receptor [Source:RGD Symbol;Acc:2902] |
| Ensembl ID | ENSRNOG00000020811 |
| Bio databases IDs | |
| Aliases | interleukin 6 receptor |
| Synonyms | CD126, Gp80, HIES5, IL-1Ra, IL6Q, IL6QTL, IL-6R-1, IL-6RA, IL-6R-alpha, Il6 receptor, IL6RQ, IL-6R-α, interleukin 6 receptor, interleukin 6 receptor, alpha, INTERLEUKIN-6 receptors, interleukin 6 receptor, α, Interleukin 6 receptor α chain |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Il6r often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ADAM17 cleavage site
- interleukin-6 receptor
- extracellular domain
- fibronectin-like domain
- cytokine binding
- PPXY motif
- immunoglobulin domain
- enzyme binding
- protein binding
- Fibronectin type 3 domain
- proline tyrosine motif
- cytokine binding module
- cytokine binding homology domain
- interleukin-6 binding
- interleukin-6 receptor binding
- ligand-binding domain
- FN3
- stalk region
- Immunoglobulin like
- protein homodimerization
- ciliary neurotrophic factor receptor
- membrane-proximal domain
- cytokine receptor
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Il6r gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- Cardiac Hypertrophy Signaling
- Colorectal Cancer Metastasis Signaling
- Glucocorticoid Receptor Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HIF1α Signaling
- IL-10 Signaling
- IL-6 Signaling
- Iron homeostasis signaling pathway
- Neuroinflammation Signaling Pathway
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NFAT in Cardiac Hypertrophy
- SPINK1 General Cancer Pathway
- STAT3 Pathway
- Systemic Lupus Erythematosus Signaling
- T Helper Cell Differentiation
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Th17 Activation Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- venous thromboembolism
- encephalopathy
- obesity
- weight loss
- schizophrenia
- pain
- dementia
- Alzheimer disease
- rheumatoid arthritis
- neoplasia
role in cell
- expression in
- proliferation
- accumulation in
- activation
- differentiation
- phosphorylation in
- quantity
- number
- apoptosis
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- synaptosomal membrane fractions
- cell surface
- Extracellular Space
- cell periphery
- cellular membrane
- apical cell surfaces
- basolateral cell surfaces
- apical membrane
- basolateral membrane
- basal membrane
- perikaryon
- plasma
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Il6r gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- interleukin-11-mediated signaling pathway
- defense response to Gram-negative bacterium
- positive regulation of cell proliferation
- extrinsic apoptotic signaling pathway
- positive regulation of leukocyte chemotaxis
- positive regulation of tyrosine phosphorylation of STAT protein
- hepatic immune response
- positive regulation of osteoblast differentiation
- acute-phase response
- positive regulation of smooth muscle cell proliferation
- monocyte chemotaxis
- cytokine-mediated signaling pathway
- ciliary neurotrophic factor-mediated signaling pathway
- T-helper 17 cell lineage commitment
- positive regulation of activation of Janus kinase activity
- interleukin-6-mediated signaling pathway
- positive regulation of glomerular mesangial cell proliferation
- positive regulation of chemokine production
- positive regulation of interleukin-6 production
- vascular endothelial growth factor production
- endocrine pancreas development
- positive regulation of peptidyl-tyrosine phosphorylation
Cellular Component
Where in the cell the gene product is active
- ciliary neurotrophic factor receptor complex
- external side of plasma membrane
- receptor complex
- extracellular region
- plasma membrane
- apical plasma membrane
- interleukin-6 receptor complex
Molecular Function
What the gene product does at the molecular level
- ciliary neurotrophic factor receptor activity
- interleukin-11 receptor activity
- protein homodimerization activity
- protein binding
- interleukin-6 receptor activity
- interleukin-6 binding
- interleukin-11 binding
- ciliary neurotrophic factor binding
- interleukin-6 receptor binding
- enzyme binding