KHSRP Gene Summary [Human]
The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010]
Details
| Type | Protein Coding |
| Official Symbol | KHSRP |
| Official Name | KH-type splicing regulatory protein [Source:HGNC Symbol;Acc:HGNC:6316] |
| Ensembl ID | ENSG00000088247 |
| Bio databases IDs | |
| Aliases | KH-type splicing regulatory protein, FUSE binding protein 2 |
| Synonyms | 6330409F21Rik, FBP2, FUBP2, KH-type splicing regulatory protein, KSRP, MARTA1, p75 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KHSRP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA 3' UTR binding
- K homology (KH) RNA-binding domain, type I
- KH domain
- mRNA binding
- enzyme
- protein binding
- K homology RNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cutaneous melanoma
- metastasis
- organismal death
- rheumatoid arthritis
- pancreatic epithelial cancer
- cutaneous melanoma cancer
- breast cancer
- neoplasia
- pancreatic ductal adenocarcinoma
- ductal pancreatic cancer
role in cell
- activation in
- expression in
- phosphorylation in
- growth
- association
- invasion by
- maturation in
- accumulation in
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- perinucleolar compartments
- nucleoplasm
- interchromatin granule clusters
- stress granule
- perikaryon
- dendrites
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KHSRP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- positive regulation of mRNA catabolic process
- 3'-UTR-mediated mRNA destabilization
- regulation of mRNA stability
- mRNA processing
- protein folding
- negative regulation of nitric oxide biosynthetic process
- regulation of transcription from RNA polymerase II promoter
- RNA splicing, via transesterification reactions
- negative regulation of low-density lipoprotein particle clearance
- cellular response to cytokine stimulus
- mRNA transport
- miRNA metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- cytosol
- exosome (RNase complex)
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding involved in protein folding
- RNA binding
- protein binding
- mRNA 3'-UTR AU-rich region binding
- mRNA binding