Cdk5rap3 Gene Summary [Rat]
Predicted to enable several functions, including MDM2/MDM4 family protein binding activity; NF-kappaB binding activity; and enzyme binding activity. Involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be located in cytosol; microtubule cytoskeleton; and nucleolus. Predicted to be part of protein-containing complex. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human CDK5RAP3 (CDK5 regulatory subunit associated protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdk5rap3 |
| Official Name | CDK5 regulatory subunit associated protein 3 [Source:RGD Symbol;Acc:620002] |
| Ensembl ID | ENSRNOG00000048747 |
| Bio databases IDs | |
| Aliases | CDK5 regulatory subunit associated protein 3 |
| Synonyms | 1810007E24Rik, C53, CDK5 regulatory subunit associated protein 3, HSF-27, IC53, LZAP, MST016, OK/SW-cl.114, PP1553 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cdk5rap3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protein kinase binding
- CDK5 regulatory subunit-associated protein 3
- NF-kappaB binding
- protein binding activity, bridging
- enzyme binding
- protein binding
- cyclin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- prostate cancer
- generalized epilepsy
- metastasis
- acute kidney injury
- complete testicular feminization syndrome
role in cell
- cell death
- expression in
- response in
- apoptosis
- proliferation
- invasion by
- disassembly
- amplification
- quantity
- endoplasmic reticulum stress response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- centrosome
- microtubules
- cytosol
- endoplasmic reticulum membrane
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cdk5rap3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- mitotic cell cycle G2/M transition DNA damage checkpoint
- negative regulation of MAP kinase activity
- ribosome disassembly
- negative regulation of protein catabolic process
- regulation of neuron differentiation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of cyclin-dependent protein kinase activity
- rescue of stalled ribosome
- endoplasmic reticulum unfolded protein response
- liver development
- positive regulation of protein ubiquitination
- positive regulation of protein localization to nucleus
- negative regulation of NF-kappaB transcription factor activity
- apoptotic nuclear change
- negative regulation of protein kinase activity by regulation of protein phosphorylation
- definitive erythrocyte differentiation
- brain development
- regulation of mitotic cell cycle
- negative regulation of protein phosphorylation
- regulation of phosphatase activity
- negative regulation of protein serine/threonine kinase activity
- response to endoplasmic reticulum stress
- protein ufmylation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- centrosome
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- cytosol
- macromolecular complex
- nucleolus
- microtubule
Molecular Function
What the gene product does at the molecular level
- NF-kappaB binding
- protein kinase binding
- protein binding
- cyclin binding
- small conjugating protein ligase binding
- mitogen-activated protein kinase binding