Sepsecs Gene Summary [Rat]
Predicted to enable tRNA binding activity. Predicted to be involved in selenocysteine incorporation. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2D. Orthologous to human SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sepsecs |
| Official Name | Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase [Source:RGD Symbol;Acc:1589491] |
| Ensembl ID | ENSRNOG00000049244 |
| Bio databases IDs | |
| Aliases | Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase |
| Synonyms | AA986712, D5Ertd135e, LP, PCH2D, SecS, Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase, SLA, SLA/LP, SLA-p35 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sepsecs often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS
- tRNA binding
- O-phosphoseryl-tRNA(Sec) selenium transferase
- AAT_I
- enzyme
- protein binding
- O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pontocerebellar hypoplasia type 2d
- hereditary disorder
- non-syndromic congenital pontocerebellar hypoplasia
- hereditary spastic ataxia
regulated by
- E. coli B5 lipopolysaccharide
- TRNAU1AP
regulates
- CYP51A1
- selenocysteine
- selenoprotein
role in cell
- endoplasmic reticulum-associated degradation in
- survival
- cohesion in
- cohesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sepsecs gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- selenocysteine incorporation
- conversion of seryl-tRNAsec to selenocys-tRNAsec
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- tRNA binding