Calu Gene Summary [Rat]
Enables calcium ion binding activity; enzyme binding activity; and enzyme inhibitor activity. Involved in peripheral nervous system axon regeneration. Located in endoplasmic reticulum lumen. Orthologous to human CALU (calumenin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Calu |
| Official Name | calumenin [Source:RGD Symbol;Acc:620383] |
| Ensembl ID | ENSRNOG00000006197 |
| Bio databases IDs | |
| Aliases | calumenin |
| Synonyms | 9530075H20RIK, CALUMENIN, Calumerin, Cbp50, MGC124555, Rcn |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Calu often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif, found in the hexa-EF hand proteins family
- EF-hand domain pair
- enzyme inhibitor activity
- calcium ion binding
- enzyme binding
- EFh
- EF-hand, calcium binding motif, found in CREC-EF hand family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- hepatocellular carcinoma
- metastasis
- rectum cancer
- epithelial cancer
- lung cancer
- cancer
- pancreatic epithelial cancer
- liver cancer
- colon adenocarcinoma
role in cell
- expression in
- inhibition in
- formation
- migration
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Extracellular Space
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- microsome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Calu gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- melanosome
- membrane
- endoplasmic reticulum
- Golgi apparatus
- extracellular region
- sarcoplasmic reticulum lumen
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding