Sash1 Gene Summary [Rat]
Predicted to enable G-protein alpha-subunit binding activity; mitogen-activated protein kinase kinase kinase binding activity; and molecular adaptor activity. Predicted to be involved in positive regulation of non-canonical NF-kappaB signal transduction and regulation of epithelial cell migration. Predicted to act upstream of or within several processes, including positive regulation of angiogenesis; positive regulation of signal transduction; and regulation of protein modification process. Predicted to be located in cytosol; membrane; and nucleoplasm. Predicted to be part of protein-containing complex. Human ortholog(s) of this gene implicated in dyschromatosis universalis hereditaria. Orthologous to human SASH1 (SAM and SH3 domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sash1 |
| Official Name | SAM and SH3 domain containing 1 [Source:RGD Symbol;Acc:1566017] |
| Ensembl ID | ENSRNOG00000013160 |
| Bio databases IDs | |
| Aliases | SAM and SH3 domain containing 1 |
| Synonyms | 1100001C18Rik, 2500002E12RIK, A330076K04Rik, CAPOK, dJ323M4.1, DUH, DUH1, FLJ13545, Image:1396616, mKIAA0790, RGD1566017, SAM and SH3 domain containing 1, SH3D6A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sash1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sterile alpha motif
- Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins
- protein kinase binding
- SAM (Sterile alpha motif )
- SAM domain (Sterile alpha motif)
- protein binding
- Lymphocyte signaling adaptor protein
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dyschromatosis universalis hereditaria type 1
- acute myeloid leukemia
- diabetic nephropathy
- cancer, alopecia, pigment dyscrasia, onychodystrophy, and keratoderma
- rotator cuff tear
- open-angle glaucoma
- myocardial infarction
role in cell
- expression in
- proliferation
- migration
- invasion by
- migration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cellular membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sash1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of JUN kinase activity
- protein polyubiquitination
- regulation of protein K63-linked ubiquitination
- regulation of epithelial cell migration
- positive regulation of lipopolysaccharide-mediated signaling pathway
- positive regulation of endothelial cell migration
- positive regulation of angiogenesis
- positive regulation of p38MAPK cascade
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- G-protein alpha-subunit binding
- mitogen-activated protein kinase kinase kinase binding
- binding, bridging