Acaca Gene Summary [Rat]
Enables acetyl-CoA carboxylase activity and biotin binding activity. Involved in fatty acid biosynthetic process; response to nutrient; and response to xenobiotic stimulus. Predicted to be located in actin cytoskeleton; cytosol; and fibrillar center. Predicted to be active in mitochondrion. Used to study steatotic liver disease. Biomarker of metabolic dysfunction-associated steatohepatitis and metabolic dysfunction-associated steatotic liver disease. Orthologous to human ACACA (acetyl-CoA carboxylase alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acaca |
| Official Name | acetyl-CoA carboxylase alpha [Source:RGD Symbol;Acc:621248] |
| Ensembl ID | ENSRNOG00000034013 |
| Bio databases IDs | |
| Aliases | acetyl-CoA carboxylase alpha |
| Synonyms | A530025K05RIK, ACAC, Acac1, ACACAD, ACACalpha, ACC, ACC1, ACCA, ACC alpha, ACC α, Acetyl-CoA carboxylase, ACETYL-COA CARBOXYLASE 1, acetyl-CoA carboxylase alpha, acetyl-CoA carboxylase α, acetyl-Coenzyme A carboxylase alpha, acetyl-Coenzyme A carboxylase α, Gm738, hACC1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Acaca often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- biotin binding
- ATP-grasp domain
- Biotin carboxylase C-terminal domain
- enzyme
- protein binding
- D-ala D-ala ligase C-terminus
- identical protein binding
- Acetyl-CoA carboxylase, central region
- Biotinyl_lipoyl_domains
- acetyl-CoA carboxylase, biotin carboxylase subunit
- kinase binding
- Carbamoyl-phosphate synthase L chain, ATP binding domain
- Biotin carboxylase, N-terminal domain
- biotin carboxylase
- Biotin-requiring enzyme
- biotin-[acetyl-CoA-carboxylase] ligase
- Carboxyl transferase domain
- PRK12999
- acetyl-CoA carboxylase
Pathways
Biological processes and signaling networks where the Acaca gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- non-insulin-dependent diabetes mellitus
- neoplasia
- insomnia
- acute myeloid leukemia
- acetyl-CoA carboxylase deficiency
- diabetic nephropathy
- chordoma
- bone cancer
- liver cancer
role in cell
- proliferation
- cell viability
- accumulation in
- apoptosis
- growth
- migration
- differentiation
- generation in
- number
- synthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- fibrillar center
- actin cytoskeleton
- cytosol
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Acaca gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tissue homeostasis
- fatty-acyl-CoA biosynthetic process
- protein metabolic process
- malonyl-CoA biosynthetic process
- protein homotetramerization
- acetyl-CoA metabolic process
- lipid homeostasis
- fatty acid biosynthetic process
- cellular response to prostaglandin E stimulus
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- actin cytoskeleton
- cytosol
- fibrillar center
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- acetyl-CoA carboxylase activity
- metal ion binding