Gart Gene Summary [Rat]
Enables phosphoribosylamine-glycine ligase activity; phosphoribosylformylglycinamidine cyclo-ligase activity; and phosphoribosylglycinamide formyltransferase activity. Involved in brainstem development; cerebellum development; and cerebral cortex development. Predicted to be active in cytosol. Orthologous to human GART (phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gart |
| Official Name | phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase [Source:RGD Symbol;Acc:1308717] |
| Ensembl ID | ENSRNOG00000028292 |
| Bio databases IDs | |
| Aliases | phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase |
| Synonyms | Adenosine3, AIRS, FTRG, Gaps, GARFT, GARS, GARTF, glycinamide ribonucleotide formyltransferase, PAIS, PGFT, phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase, PRGS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gart often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
- phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent
- glycinamide ribonucleotide transformylase domain
- AIR synthase related protein, N-terminal domain
- ATP-grasp domain
- PurM-like
- enzyme
- phosphoribosylamine--glycine ligase
- phosphoribosylformylglycinamidine cyclo-ligase
- RimK-like ATP-grasp domain
- Phosphoribosylglycinamide synthetase, N domain
- Carbamoyl-phosphate synthase L chain, ATP binding domain
- Phosphoribosylglycinamide synthetase, C domain
- phosphoribosylamine-glycine ligase
- phosphoribosylglycinamide formyltransferase
- aminoimidazole ribonucleotide synthetase domain
- Formyltransferase, catalytic core domain
- phosphoribosylaminoimidazole synthetase
- AIR synthase related protein, C-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- advanced non-squamous non-small cell lung cancer
- metastatic non-squamous non-small cell lung cancer
- advanced non-small cell lung cancer
- recurrent nonsquamous non-small cell lung cancer
- locally advanced nonsquamous non-small cell lung cancer
- non-small cell lung cancer
- metastatic non-small cell lung cancer
- lung adenocarcinoma
- metastatic lung adenocarcinoma
role in cell
- migration
- expression in
- proliferation
- phosphorylation in
- polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gart gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- 'de novo' AMP biosynthetic process
- purine nucleotide biosynthetic process
- cerebellum development
- 'de novo' IMP biosynthetic process
- brainstem development
- purine ribonucleoside monophosphate biosynthetic process
- GMP biosynthetic process
- tetrahydrofolate biosynthetic process
- cerebral cortex development
- 'de novo' XMP biosynthetic process
- glycine metabolic process
- adenine biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- phosphoribosylglycinamide formyltransferase activity
- ATP binding
- metal ion binding
- phosphoribosylamine-glycine ligase activity
- phosphoribosylformylglycinamidine cyclo-ligase activity