Gstm5 Gene Summary [Rat]
Enables glutathione transferase activity and identical protein binding activity. Predicted to be involved in several processes, including cellular detoxification of nitrogen compound; nitrobenzene metabolic process; and response to estrogen. Predicted to be located in cytosol and sperm fibrous sheath. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; cystic fibrosis; larynx cancer; multiple sclerosis; and osteosarcoma. Orthologous to human GSTM3 (glutathione S-transferase mu 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gstm5 |
| Official Name | glutathione S-transferase, mu 5 [Source:RGD Symbol;Acc:61964] |
| Ensembl ID | ENSRNOG00000049743 |
| Bio databases IDs | |
| Aliases | glutathione S-transferase, mu 5 |
| Synonyms | Glutathione S-transferase mu 3, glutathione S-transferase, mu 5, GST5, GSTB, GSTM3-3, GSTM3TV2, Gstm5, GTM3, hGSTM3-3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gstm5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione S-transferase, C-terminal domain
- Glutathione S-transferase, N-terminal domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- binding protein
- glutathione transferase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- enzyme binding
- protein homodimerization
- enzyme
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Gstm5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- aortic valve calcification
- thrombocytopenia
- osteosarcoma
- osteosarcomagenesis
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- anemia
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- ototoxicity
regulates
- 4-hydroxynonenal
- glutathione
- carmustine
- cumene hydroperoxide
- p-nitrophenyl acetate
- ethacrynic acid
- 3,4-dichloronitrobenzene
- 1-chloro-2,4-dinitrobenzene
- monohydroperoxy-linoleic acid
- trans-4-phenylbut-3-en-2-one
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- sperm fibrous sheath
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gstm5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to estrogen stimulus
- nitrobenzene metabolic process
- glutathione metabolic process
- establishment of blood-nerve barrier
- xenobiotic catabolic process
- cellular detoxification of nitrogen compound
Cellular Component
Where in the cell the gene product is active
- nucleus
- intercellular bridge
- extracellular vesicular exosome
- cytoplasm
- cytosol
- flagellar fibrous sheath
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein homodimerization activity
- protein binding
- glutathione binding
- glutathione transferase activity
- enzyme binding