LOC100912163 Gene Summary [Rat]
This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | LOC100912163 |
| Official Name | AT-rich interactive domain-containing protein 4B-like [Source:RGD Symbol;Acc:6488837] |
| Ensembl ID | ENSRNOG00000049751 |
| Bio databases IDs | |
| Aliases | AT-rich interactive domain-containing protein 4B-like |
| Synonyms | AT-rich interaction domain 4B, BCAA, BRCAA1, LOC100912163, RBBP1L1, RBP1L1, RBP1-LIKE, SAP180 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Loc100912163 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Chromatin organization modifier domain
- transcription regulator
- r1 domain
- RBB1NT (NUC162) domain
- PWWP (Pro-Trp-Trp-Pro) domain
- protein binding
- ARID/BRIGHT DNA binding domain
- malignant brain tumor (MBT) repeat
- DNA binding
- R2 domain
- CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
- Tudor domain superfamily
- ARID/BRIGHT DNA binding domain family
Pathways
Biological processes and signaling networks where the Loc100912163 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- leukemia
- hemophagocytosis
- psychosis
- femoral fracture
- agenesis
- acute myeloid leukemia
- hypogonadism
- thrombocytopenia
- asthma
role in cell
- number
- migration
- expression in
- apoptosis
- quantity
- proliferation
- development
- organization
- co-activation in
- spermatogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Loc100912163 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- spermatogenesis
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- genetic imprinting
- negative regulation of transforming growth factor beta receptor signaling pathway
- negative regulation of cell migration
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- cytosol
- nucleoplasm
- Sin3-type complex
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- transcription regulatory region sequence-specific DNA binding