Atp5f1e Gene Summary [Rat]
Contributes to ATP hydrolysis activity. Predicted to be involved in proton motive force-driven mitochondrial ATP synthesis. Located in mitochondrial inner membrane. Part of proton-transporting ATP synthase complex. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 3. Orthologous to several human genes including ATP5F1E (ATP synthase F1 subunit epsilon). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp5f1e |
| Official Name | ATP synthase F1 subunit epsilon [Source:RGD Symbol;Acc:621374] |
| Ensembl ID | ENSRNOG00000049912 |
| Bio databases IDs | |
| Aliases | ATP synthase F1 subunit epsilon |
| Synonyms | 2410043G19Rik, ATP5E, ATPE, Atp Synthase Epsilon, ATP synthase F1 subunit epsilon, ATP synthase F1 subunit ε, Atp Synthase ε, H+ ATP Synthase Epsilon, H+ ATP Synthase ε, MC5DN3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atp5f1e often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- eukaryotic mitochondrial ATP synthase epsilon subunit
- protein binding
- hydrogen-transporting ATP synthase activity, rotational mechanism
- H+-exporting ATPase
- ATPase
- transporter
Pathways
Biological processes and signaling networks where the Atp5f1e gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- hepatocellular carcinoma
- non-insulin-dependent diabetes mellitus
- metabolic syndrome X
- mitochondrial complex V deficiency nuclear type 3
- liver cancer
- epithelial cancer
- Huntington disease
regulates
- PRKCA
- H+
- ADCY
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cristae-like membrane
- cell cortex
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atp5f1e gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ATP synthesis coupled proton transport
- mitochondrial ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)
- mitochondrial matrix
- mitochondrial inner membrane
- mitochondrial proton-transporting ATP synthase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- hydrogen ion transporting ATP synthase activity, rotational mechanism
- hydrolase activity