Notch3 Gene Summary [Rat]
Predicted to enable enzyme binding activity; identical protein binding activity; and signaling receptor activity. Involved in several processes, including Notch signaling pathway; cellular response to platelet-derived growth factor stimulus; and tissue regeneration. Predicted to be located in nucleoplasm. Predicted to be part of receptor complex. Predicted to be active in cell surface and plasma membrane. Human ortholog(s) of this gene implicated in CADASIL 1; infantile myofibromatosis; and lateral meningocele syndrome. Orthologous to human NOTCH3 (notch receptor 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Notch3 |
| Official Name | notch receptor 3 [Source:RGD Symbol;Acc:620761] |
| Ensembl ID | ENSRNOG00000004346 |
| Bio databases IDs | |
| Aliases | notch receptor 3 |
| Synonyms | AW229011, CADASIL, CADASIL1, CASIL, hpbk, IMF2, LMNS, N3, notch receptor 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Notch3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- transcription regulator
- Ankyrin repeats (many copies)
- JMTM_Notch_APP
- RAM domain
- signaling receptor activity
- ectodomain
- Human growth factor-like EGF
- LNR domain
- Ankyrin repeats (3 copies)
- enzyme binding
- protein binding
- identical protein binding
- EGF-like domain
- EGF_CA
- NOTCH protein
- intracellular domain
- EGF domain
- EGF repeat
Pathways
Biological processes and signaling networks where the Notch3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pulmonary hypertensive arterial disease
- cancer
- epithelial neoplasia
- epithelial cancer
- digestive system cancer
- abdominal cancer
- leukemia
- neoplasia
- non-insulin-dependent diabetes mellitus
- hereditary disorder
role in cell
- binding in
- quantity
- expression in
- apoptosis
- phosphorylation in
- activation in
- proliferation
- migration
- growth
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- intracellular space
- perinuclear region
- cellular membrane
- Nucleus
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Notch3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of smooth muscle cell proliferation
- negative regulation of transcription from RNA polymerase II promoter
- forebrain development
- Notch signaling pathway
- neuron fate commitment
- negative regulation of neuron differentiation
- axon guidance
- artery morphogenesis
- glomerular capillary formation
- positive regulation of transcription from RNA polymerase II promoter
- neuroblast differentiation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytosol
- Golgi membrane
- receptor complex
- extracellular region
- plasma membrane
- cell surface
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- cadherin binding
- calcium ion binding
- signaling receptor activity
- enzyme binding