Rcc1 Gene Summary [Rat]
Predicted to enable several functions, including guanyl-nucleotide exchange factor activity; nucleosomal DNA binding activity; and protein heterodimerization activity. Predicted to be involved in G1/S transition of mitotic cell cycle; regulation of cell cycle process; and spindle organization. Predicted to be located in chromatin; condensed nuclear chromosome; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Orthologous to human RCC1 (regulator of chromosome condensation 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rcc1 |
| Official Name | regulator of chromosome condensation 1 [Source:RGD Symbol;Acc:1592835] |
| Ensembl ID | ENSRNOG00000050106 |
| Bio databases IDs | |
| Aliases | regulator of chromosome condensation 1 |
| Synonyms | 4931417M11Rik, CHC1, RCC1-I, regulator of chromosome condensation 1, RENAL CELL CARCINOMA 1, SNHG3-RCC1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rcc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- Regulator of chromosome condensation (RCC1) repeat
- binding protein
- guanyl-nucleotide exchange factor
- nuclear localization sequence
- enzyme binding
- chromatin binding
- protein binding
- protein heterodimerization
- DNA binding
- phosphorylation site
Pathways
Biological processes and signaling networks where the Rcc1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- glioblastoma
- lymphoma
- prostate cancer
- liver cancer
- Waldenström macroglobulinemia
- colon epithelial cancer
- hepatocellular carcinoma
- gastric adenocarcinoma
- gastric epithelial cancer
role in cell
- proliferation
- quantity
- cell cycle progression
- morphology
- assembly
- reassembly
- segregation
- repair in
- mitosis
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- chromosome
- nuclear pores
- nucleoplasm
- chromatin
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rcc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- spindle assembly
- mitotic nuclear envelope reassembly
- regulation of mitosis
- mitotic spindle organization
- G1/S transition of mitotic cell cycle
- viral reproduction
- chromosome segregation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- macromolecular complex
- chromosome
- chromatin
- nucleoplasm
- condensed nuclear chromosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein heterodimerization activity
- histone binding
- nucleosome binding
- guanyl-nucleotide exchange factor activity
- nucleosomal DNA binding
- sulfate binding
- small GTPase binding
- chromatin binding