Hdac9 Gene Summary [Rat]
Predicted to enable several functions, including enzyme binding activity; histone deacetylase activity, hydrolytic mechanism; and transcription corepressor activity. Involved in neuron differentiation and response to amphetamine. Predicted to be located in cytoplasm and nucleus. Predicted to be part of histone deacetylase complex; histone methyltransferase complex; and transcription regulator complex. Biomarker of middle cerebral artery infarction. Orthologous to human HDAC9 (histone deacetylase 9). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hdac9 |
| Official Name | histone deacetylase 9 [Source:RGD Symbol;Acc:1310748] |
| Ensembl ID | ENSRNOG00000004158 |
| Bio databases IDs | |
| Aliases | histone deacetylase 9 |
| Synonyms | AK143298, ARCND4, AV022454, D030072B18, D030072B18Rik, HD7, HD7B, HD9, HDAC, HDAC7, HDAC7B, HDAC9B, HDAC9FL, HDAC C, HDRP, histone deacetylase 9, LOC100504541, LOC100861990, LOC102552384, MITR, mKIAA0744, RGD1310748, RGD1563092 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hdac9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MEF2 binding domain
- CtBP binding domain
- transcription regulator
- catalytic domain
- transcription co-repressor
- protein kinase C binding
- nuclear localization sequence
- transcription factor binding
- histone deacetylase binding
- protein binding
- Arginase-like and histone-like hydrolases
- protein deacetylase activity
- basic helix-loop-helix-leucine zipper domain
- linear amide carbon-nitrogen bond hydrolase
- ClassIIa_HDAC_Gln-rich-N
- histone deacetylase
- Glutamine rich N terminal domain of histone deacetylase 4
Pathways
Biological processes and signaling networks where the Hdac9 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- Bladder Cancer Signaling
- Calcium Signaling
- Chronic Myeloid Leukemia Signaling
- Cyclins and Cell Cycle Regulation
- Glioma Signaling
- Hereditary Breast Cancer Signaling
- Huntington's Disease Signaling
- Molecular Mechanisms of Cancer
- Non-Small Cell Lung Cancer Signaling
- Nur77 Signaling in T Lymphocytes
- Ovarian Cancer Signaling
- p53 Signaling
- Pancreatic Adenocarcinoma Signaling
- Prostate Cancer Signaling
- Role of NFAT in Cardiac Hypertrophy
- Small Cell Lung Cancer Signaling
- Telomerase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- diffuse large B-cell lymphoma
- peripheral T-cell lymphoma
- relapsed peripheral T-cell lymphoma
- enteropathy-associated T-cell lymphoma
- angioimmunoblastic T-cell lymphoma
- epilepsy
- maculopapular rash
- tubulo-interstitial fibrosis
- non-insulin-dependent diabetes mellitus
role in cell
- cell death
- expression in
- binding in
- apoptosis
- acetylation in
- differentiation
- molecular cleavage in
- activation
- organization
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hdac9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression, epigenetic
- B cell differentiation
- neuron differentiation
- B cell activation
- positive regulation of cell migration involved in sprouting angiogenesis
- cholesterol homeostasis
- negative regulation of transcription from RNA polymerase II promoter
- cellular response to insulin stimulus
- heart development
- inflammatory response
- negative regulation of transcription, DNA-dependent
- response to amphetamine
- regulation of skeletal muscle fiber development
- regulation of striated muscle cell differentiation
- peptidyl-lysine deacetylation
- negative regulation of cytokine production
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- cytoplasm
- histone methyltransferase complex
- histone deacetylase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- histone deacetylase activity (H4-K16 specific)
- protein binding
- histone deacetylase binding
- histone deacetylase activity
- metal ion binding
- transcription corepressor activity
- histone deacetylase activity (H3-K14 specific)
- protein deacetylase activity
- histone deacetylase activity (H3-K9 specific)