Safb Gene Summary [Rat]
Enables sequence-specific DNA binding activity. Involved in regulation of mRNA processing and regulation of transcription by RNA polymerase II. Predicted to be located in midbody and nucleoplasm. Predicted to be active in nucleus. Orthologous to human SAFB (scaffold attachment factor B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Safb |
| Official Name | scaffold attachment factor B [Source:RGD Symbol;Acc:620613] |
| Ensembl ID | ENSRNOG00000050543 |
| Bio databases IDs | |
| Aliases | scaffold attachment factor B |
| Synonyms | 3110021E02RIK, 5330423C17RIK, AU018122, D18386, E130307D12, HAP, HET, SAB-B1, SAF-B1, scaffold attachment factor B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Safb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- SAP motif
- RNA recognition motif
- nucleic acid binding
- SAP domain
- central domain
- chromatin binding
- protein binding
- sequence-specific DNA binding
- transcription repression domain
- SAF-box
- double-stranded DNA binding
- glycine arginine rich domain
Pathways
Biological processes and signaling networks where the Safb gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- postmenopausal osteoporosis
- infection by HIV-1
role in cell
- expression in
- replication in
- growth
- transcription in
- binding in
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- perinuclear region
- midbody
- nucleoplasm
- nuclear matrix
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Safb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mRNA processing
- chromatin organization
- intracellular estrogen receptor signaling pathway
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- midbody
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- double-stranded DNA binding
- sequence-specific DNA binding
- chromatin binding